Marrow Cellution™ And Percutaneous Cancellous Bone Harvesting System

Marrow Cellution™ and Percutaneous Cancellous Bone Harvesting System

This convenient kit includes both the Marrow Cellution™ BMA needle for acquisition of bone marrow aspirate and an 8 gauge bone marrow biopsy needle used for percutaneous trephine extraction of autogenous bone marrow/cancellous bone dowels.

Higher quality, less quantity, delivered appropriately minimizes host morbidity. Bone marrow aspiration and trephine extraction of cancellous bone are considered minimally invasive techniques compared to open methods of bone extraction and has been documented to have less donor site morbidity than open procedures.(1,2,3). Additionally, bone marrow aspirate is commonly used in bone grafting procedures as it serves as a rich source of osteoprogenitor cells, and autograft bone is the “gold standard” clinical material for grafting.(4,5)

Intact Bone Cores vs. Morselized Bone

Harvesting intact cancellous bone cores without disrupting the highly-organized living tissue is superior to transplanting pieces of bone. Intact grafts maintain the micro-vascular network within the graft, promoting bone callus formation/remodeling and do not exhibit extensive resorption. (6,7) Intact bone exploits the biology of normal fracture healing rather than through slow creeping substitution associated with the slow incorporation of a non-vascularized graft. (6) Research demonstrates the enhanced survival of a bone graft as long as its primary blood supply is preserved. A living bone graft will shorten the time for bony onion because the reconstructed bone is comparable to a bone with a double fracture. (6,7) Allogeneic or synthetic bone chips hydrated with marrow can be packed around the living bone graft/core to accelerate anastomosis into the graft and minimize morbidity.

Sources

  1. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011783/full accessed on 13 Nov 2018.
  2. Missiuna PC, Gandhi HS, Farrokhyar F, Harnett BE, Dore EM, Roberts B. Anatomically safe and minimally invasive transcrestal technique for procurement of autogenous cancellous bone graft from the mid-iliac crest. Can J Surg. 2011;54(5):327-32.
  3. Hernigou P, Descroches A, Quennec S, Flousat Lachaniette CH, Poignard A, Allain J, Chevallier N, Rouard H. Morbidity of graft harvesting versus bone marrow aspiration in cell regenerative therapy. Int Orthop. 2014 Sep;38(9):1855-60
  4. Block JE. The role and effectiveness of bone marrow in osseous regeneration. Med Hypotheses. 2005;65(4):740-7.
  5. Wang W, Yeung K. Bone grafts and biomaterials substitutes for bone defect repair. A review. Bioactive Materials. 2017;2(4):224-227.
  6. Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, Ten Kate FJ, van Deventer SJ, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li L, van den Brink GR (Sep 2007). “Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice”. Cancer Research. 67 (17): 8149–55.
  7. Ostrup et al Distant transfer of a free, living bone graft by micro-vascular anastomoses. An experimental study. Plast Reconstr. Surg. 1974 Sep; 54(3): 274-85